Title

Enhanced Antiscrapie Effect Using Combination Drug Treatment

Document Type

Article

Journal/Book Title/Conference

Antimicrobial Agents and Chemotherapy

Volume

50

Issue

10

Publisher

American Society for Microbiology

Publication Date

2006

First Page

3447

Last Page

3449

DOI

10.1128/AAC.00715-06

Abstract

Combination treatment with pentosan polysulfate and Fe(III)meso-tetra(4-sulfonatophenyl)porphine in mice beginning 14 or 28 days after scrapie inoculation significantly increased survival times. This increase may be synergistic, implying that the compounds act cooperatively in vivo. Combination therapy may therefore be more effective for treatment of transmissible spongiform encephalopathies and other protein-misfolding diseases.