Title

A Porphyrin Increases Survival Time of Mice after Intracerebral Prion Infection

Document Type

Article

Journal/Book Title/Conference

Antimicrobial Agents and Chemotherapy

Volume

50

Issue

2

Publisher

American Society for Microbiology

Publication Date

2006

First Page

759

Last Page

761

DOI

10.1128/AAC.50.2.759-761.2006

Abstract

Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.