Title

Potent in vitro activity of the albumin fusion type 1interferons (albumin-interferon-alpha and albumin-interferon-beta) against RNA viral agentsof bioterrorism and the severe acute respiratory syndrome (SARS) virus

Document Type

Article

Journal/Book Title/Conference

Chemotherapy

Volume

54

Issue

3

Publication Date

2008

First Page

176

Last Page

180

Abstract

Background: The type 1 interferons (INF-α and INF-β) are potent antiviral agents. Albumin-INF-α and albumin-INF-β are novel recombinant proteins consisting of IFN-α or IFN-β genetically fused to human albumin. Methods: The in vitro antiviral activity of albumin-IFN-α was evaluated against representative bioterrorism viral agents and the severe acute respiratory syndrome virus. Antiviral activity was assessed using inhibition of cytopathic effect and neutral red staining. Results: EC50 values for albumin-IFN-α ranged fromConclusion: Further evaluation of these long-acting albumin-IFN fusion proteins as prophylactic or therapeutic agents against these viral agents of bioterrorism in relevant primate models is warranted.

Comments

Chemotherapy 54: 176-180. PMID: 18560223