Potent in vitro activity of the albumin fusion type 1interferons (albumin-interferon-alpha and albumin-interferon-beta) against RNA viral agentsof bioterrorism and the severe acute respiratory syndrome (SARS) virus
Background: The type 1 interferons (INF-α and INF-β) are potent antiviral agents. Albumin-INF-α and albumin-INF-β are novel recombinant proteins consisting of IFN-α or IFN-β genetically fused to human albumin. Methods: The in vitro antiviral activity of albumin-IFN-α was evaluated against representative bioterrorism viral agents and the severe acute respiratory syndrome virus. Antiviral activity was assessed using inhibition of cytopathic effect and neutral red staining. Results: EC50 values for albumin-IFN-α ranged fromConclusion: Further evaluation of these long-acting albumin-IFN fusion proteins as prophylactic or therapeutic agents against these viral agents of bioterrorism in relevant primate models is warranted.
Subramanian, G.M., Moore, P.A., Gowen, B.B., Olsen, A.L., Barnard, D.L., Paragas, J., Hogan, R.J. and Sidwell, R.W. 2008. Potent in vitro activity of the albumin fusion type 1 interferons (albumin-interferon-alpha and albumin-interferon-beta) against RNA viral agents of bioterrorism and the severe acute respiratory syndrome (SARS) virus. Chemotherapy 54: 176-180. PMID: 18560223