The Distribution, Elimination, and Metabolism of ¹⁴C-Alternariol Monomethyl Ether

Authors

G. A. Pollock, University of Idaho
C. E. DiSabotino, University of Idaho
R. C. Heimsch, University of Idaho
Roger A. Coulombe Jr., University of IdahoFollow

Document Type

Article

Journal/Book Title/Conference

Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes

Volume

17

Issue

2

Publisher

Taylor & Francis

Publication Date

1982

First Page

109

Last Page

124

Abstract

Adult male Sprague-Dawley rats were orally administered ¹⁴C-alternariol monomethyl ether (AME) in olive oil and housed in glass metabolism cages. Urine, feces, and expired CO₂ were monitored for the presence of radioactivity. The majority of activity was excreted in the feces apparently unabsorbed. Urine excretion accounted for less than 10% of the administered dose. A substantial amount of "absorbed"; activity was excreted in expired CO₂. TLC autoradiography of urine extracts revealed extensive metabolism, but little metabolism was evident in feces extracts. Incubation of AME with rat liver post-mitochondrial supernatant also resulted in substantial metabolism.

Comments

Originally published by Taylor & Francis Group. Abstract available through remote link. Subscription required to access article fulltext.

Recommended Citation

Pollock, G.A., C.E. DiSabotino, R.C. Heimsch and R.A. Coulombe, Jr. (1982). Distribution, elimination and metabolism of 14C-alternariol monomethylether. J. Environ. Sci. Health B 17:109-124.