Ionophore use and toxicosis in cattle

Document Type

Article

Journal/Book Title/Conference

Veterinary Clinics of North America: Food Animal Practice

Volume

16

Issue

3

Editor

Gary Osweiler and Frank Galey

Publisher

NCBI

Publication Date

2000

First Page

497

Last Page

509

Abstract

Ionophores comprise a rapidly expanding class of antibiotics produced by filamentous branching bacteria of the order Actinomycetales. The use of ionophores as coccidiostats and growth promotants has resulted in the occurrence of toxicoses in target and nontarget species. Clinical and pathologic effects of ionophore poisoning are caused by bioactivity and damage to excitable tissues such as cardiac muscle, skeletal muscle, smooth muscle, and the nervous system. Ionophore toxicoses are often related to errors in feed mixing, so the practitioner should give primary importance to the removal of suspect feeds and testing to confirm excessive exposure.

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