The Cytochrome P4501A5 Gene in the Turkey (Meleagris gallopavo)
International Society for Animal Genetics Conference
International Society for Animal Genetics
The Cytochrome P450 gene (CYP1A5) encodes the primary protein responsible for epoxidation of the mycotoxin aflatoxin B1 (AFB1) in the turkey. Hypersensitivity of turkeys to AFB1 was associated with “Turkey X Disease” which caused widespread deaths of turkeys and other poultry throughout Europe in the 1960s. Comparative genomic approaches were used to selectively amplify and sequence the introns and 3’flanking region of CYP1A5. A single nucleotide polymorphism in the 3’UTR was used to genetically map CYP1A5 to turkey linkage group M16. The results of this study provide the framework for identifying allelic variants of this biochemically important P450 gene in poultry.
Reed, K.M. and R.A. Coulombe, Jr. The Cytochrome P4501A5 gene in the turkey (Meleagris gallopavo). Presented at the International Society for Animal Genetics conference, Porto Seguro, Brazil, August, 2006.