Extracellular Matrix Vesicles in Endochondral Bone Development and in Healing After Injury

Authors

J. Sela, The Hebrew University Hadassah Faculty of Dental Medicine
Z. Schwartz, The Hebrew University Hadassah Faculty of Dental Medicine
L. D. Swain, The University of Texas Health Science Center
D. Amir, The Hebrew University Hadassah Faculty of Dental Medicine
B. D. Boyan, The University of Texas Health Science Center

Abstract

Matrix vesicles are fundamental components of initial mineral formation in endochondral and primary ossification. Regulation of their structure and function is multi-faceted and involves genomic and nongenomic pathways. Their function in mineralization may include matrix maturation and conveying cellular signals to the extracellular matrix as well. Intravesicular hydroxyapatite crystal formation is associated with primary mineralization; subsequent crystal formation, particularly at later stages, appears to be mediated by other mechanisms.

Recommended Citation

Sela, J.; Schwartz, Z.; Swain, L. D.; Amir, D.; and Boyan, B. D. (1992) "Extracellular Matrix Vesicles in Endochondral Bone Development and in Healing After Injury," Cells and Materials: Vol. 2: No. 2, Article 6.
Available at: https://digitalcommons.usu.edu/cellsandmaterials/vol2/iss2/6