In this study, hydroxyapatite, tetracalcium phosphate, HPEO/PBT 55145 copolymer, PEO/PBT 55!45 copolymer (Polyactive) and silicone rubber were implanted as dense blocks, subcutaneously and. into the tibia of rats. Biocompatibility and degradation were investigated but most attention was directed to .the bone/biomaterial interactions. None of the materials showed any significant adverse tissue reactions. With exception of the silicone rubber, all materials sho~ed bone bonding phenomena based on both morphological and mechanical evaluations. (H)PEO/PBT 55145 copolymer is the first polymer reported to be bonded by bone and thus widens the spectrum of bone bonding materials with a low modulus, degradable, elastomer in contrast to the high modulus glasses and ceramics that are available to date. The possible associated bone-bonding mechanism is briefly discussed.
van Blitterswijk, C. A.; de Wijn, J. R.; Leenders, H.; Brink, J. v.d.; Hesseling, S. C.; and Bakker, D.
"A Comparative Study of the Interactions of Two Calcium Phosphates, PEO/PBT Copolymer (Polyactive) and a Silicone Rubber with Bone and Fibrous Tissue,"
Cells and Materials: Vol. 3
, Article 9.
Available at: http://digitalcommons.usu.edu/cellsandmaterials/vol3/iss1/9