Cell-Degradation of Calcium Phosphate Ceramics

Authors

P. Frayssinet, Bioland, Toulouse
N. Rouquet, Bioland, Toulouse
F. Tourenne, Bioland, Toulouse
J. Fages, Bioland, Toulouse
D. Hardy, Hospital St. Pierre, Bruxelles
G. Bonel, Bioland, Toulouse

Abstract

Calcium phosphate ceramics are used in bone surgery under different forms: dense or porous ceramic s as bone substitute, thin ceramic coatings on metallic implants as an osseointegration enhancer. Their degradation depends on their physico-chemical properties and particularly on their chemical composition. Natural calcium phosphates of bone are degraded by mononuclear or multinuclear cells and the extracellular matrix induces the differentiation of the degrading-cells. Hydroxyapatite, which is one of the most used calcium phosphates , is known as a low degradation material. However, the histological analysis of implanted HA-materials both in animals and in humans showed that a cellular degradation took place on the surface of the material.

Recommended Citation

Frayssinet, P.; Rouquet, N.; Tourenne, F.; Fages, J.; Hardy, D.; and Bonel, G. (1993) "Cell-Degradation of Calcium Phosphate Ceramics," Cells and Materials: Vol. 3: No. 4, Article 6.
Available at: https://digitalcommons.usu.edu/cellsandmaterials/vol3/iss4/6