Investigation of the Regioselectivity for the Staudinger Reaction and Its Application for the Synthesis of Aminoglycosides with N-1 Modification

Authors

Jie Li, Utah State University
Fang-I Chiang, Utah State University
Hsiao-Nung Chen, Utah State University
Cheng-Wei Tom Chang, Utah State UniversityFollow

Document Type

Article

Journal/Book Title

Journal of Organic Chemistry

Publication Date

5-1-2007

Publisher

American Chemical Society

Volume

72

Issue

11

First Page

4055

Last Page

4066

Abstract

The criteria for controlling the regioselectivity of Staudinger reduction of azides have been investigated. These findings enable a convenient direct N-1 modification of the perazidoneamine and perazidoribostamycin resulting in the synthesis of aminoglycoside antibiotics with activity against drug-resistant bacteria.

Comments

PubMed PMID: 17465564; PubMed Central PMCID: PMC2553255

Recommended Citation

Li, J.; Chiang, F.-I.; Chen, H.-N.; Chang, C.-W. T. “Investigation of the Regioselectivity for Staudinger Reaction and Its Application for the Synthesis of Aminoglycosides with N-1 Modification.” J. Org. Chem. 2007, 72, 4055-4066. PubMed PMID: 17465564; PubMed Central PMCID: PMC2553255.