Synthesis and anticancer activity studies of cyclopamine derivatives

Authors

Jianjun Zhang, Utah State University
Massoud Garrossian, Logan Natural Product
Dale Gardner, USDA ARS Poisonous Plant Research Laboratory
Arash Garrossian, Utah State University
Young-Tae Chang, National University of Singapore
Yun Kyung Kim, National University of Singapore
Cheng-Wei Tom Chang, Utah State UniversityFollow

Document Type

Article

Journal/Book Title

Bioorganic & Medicinal Chemistry Letters

Publication Date

2-15-2008

Publisher

Elsevier

Volume

18

Issue

4

First Page

1359

Last Page

1363

Abstract

A diversity-oriented synthesis has been developed for facile construction of a library of carbohydrate–cyclopamine conjugates. The synthetic protocol is suitable for generating cyclopamine derivatives with various structural motifs for exploring the desired activity. From this initial library, we have observed one derivative that exhibits improved activity against lung cancer cell as compared to cyclopamine

Comments

PubMed PMID: 18221872

Recommended Citation

Zhang, J.; Garrossian, M.; Gardner, D.; Garrossian, A.; Chang, Y.-T.; Kim, Y. K.; Chang, C.-W. T. “Synthesis and Anticancer Activity Studies of Cyclopamine Derivatives.” Bioorg. Med. Chem. Lett. 2008, 18, 1359-1363. PubMed PMID: 18221872.