Synthesis of bioactive 1-alkyl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-diones and N-aryl-2-aminomethylene-1,3-indanediones using water as the solvent

Authors

Qian Zhang, Utah State University
Jaya P. Shrestha, Utah State University
Cheng-Wei Tom Chang, Utah State UniversityFollow

Document Type

Article

Journal/Book Title

Tetrahedron Letters

Publication Date

3-5-2014

Publisher

Elsevier

Volume

55

Issue

10

First Page

1839

Last Page

1842

Abstract

Through a [2+3] cycloaddition reaction, a new environmentally friendly method was developed to enable the synthesis of bioactive 1-alkyl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-diones and N-aryl-2-aminomethylene-1,3-indanediones using water as the solvent with good yields and minimum requirement of purification. This new green synthetic protocol is simple and suitable for scale-up synthesis.

Recommended Citation

Zhang, Q.; Shrestha, J. P.; Chang, C.-W. T. "Synthesis of bioactive 1-alkyl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-diones and N-aryl-2-aminomethylene-1,3-indanediones using water as the solvent." Tetrahedron Lett. 2014, 55, 1839-1842.