Title of Oral/Poster Presentation

In vitro Antioxidant Treatment Model for Oxidative Stress in Simulated Microgravity

Class

Article

Graduation Year

2017

College

College of Engineering

Department

Biological Engineering Department

Faculty Mentor

Dr. Elizabeth Vargis

Presentation Type

Oral Presentation

Abstract

Muscular atrophy, or loss of muscle mass, is prevalent when muscle use is limited by immobilization on earth, or in microgravity when muscle tissue is not exercised by regular loading. Oxidative stress increases with limited muscle use and as astronauts are exposed to ionizing radiation during space travel. This oxidative stress kills muscles cells, causing even further breakdown of the tissue and damage to DNA, increasing cancer risk. We propose that by introducing a variety of antioxidants to combat oxidative stress on murine C2C12 muscle cells that muscular atrophy, ionizing radiation damage, and cell death can be greatly a reduced.

Location

Room 154

Start Date

13-4-2017 3:00 PM

End Date

13-4-2017 4:15 PM

This document is currently not available here.

Share

COinS
 
Apr 13th, 3:00 PM Apr 13th, 4:15 PM

In vitro Antioxidant Treatment Model for Oxidative Stress in Simulated Microgravity

Room 154

Muscular atrophy, or loss of muscle mass, is prevalent when muscle use is limited by immobilization on earth, or in microgravity when muscle tissue is not exercised by regular loading. Oxidative stress increases with limited muscle use and as astronauts are exposed to ionizing radiation during space travel. This oxidative stress kills muscles cells, causing even further breakdown of the tissue and damage to DNA, increasing cancer risk. We propose that by introducing a variety of antioxidants to combat oxidative stress on murine C2C12 muscle cells that muscular atrophy, ionizing radiation damage, and cell death can be greatly a reduced.