Potent in vitro activity of the albumin fusion type 1interferons (albumin-interferon-alpha and albumin-interferon-beta) against RNA viral agentsof bioterrorism and the severe acute respiratory syndrome (SARS) virus

Authors

G. M. Subramanian
P. A. Moore
Brian B. Gowen, Utah State UniversityFollow
Aaron L. Olsen, Utah State UniversityFollow
Dale L. Barnard, Utah State UniversityFollow
J. Paragas
R. J. Hogan
R. W. Sidwell, Utah State University

Document Type

Article

Journal/Book Title/Conference

Chemotherapy

Volume

54

Issue

3

Publication Date

2008

First Page

176

Last Page

180

Abstract

Background: The type 1 interferons (INF-α and INF-β) are potent antiviral agents. Albumin-INF-α and albumin-INF-β are novel recombinant proteins consisting of IFN-α or IFN-β genetically fused to human albumin. Methods: The in vitro antiviral activity of albumin-IFN-α was evaluated against representative bioterrorism viral agents and the severe acute respiratory syndrome virus. Antiviral activity was assessed using inhibition of cytopathic effect and neutral red staining. Results: EC₅₀ values for albumin-IFN-α ranged fromConclusion: Further evaluation of these long-acting albumin-IFN fusion proteins as prophylactic or therapeutic agents against these viral agents of bioterrorism in relevant primate models is warranted.

Comments

Chemotherapy 54: 176-180. PMID: 18560223

Recommended Citation

Subramanian, G.M., Moore, P.A., Gowen, B.B., Olsen, A.L., Barnard, D.L., Paragas, J., Hogan, R.J. and Sidwell, R.W. 2008. Potent in vitro activity of the albumin fusion type 1 interferons (albumin-interferon-alpha and albumin-interferon-beta) against RNA viral agents of bioterrorism and the severe acute respiratory syndrome (SARS) virus. Chemotherapy 54: 176-180. PMID: 18560223