Activation of the human immunodeficiency virus type 1 long terminal repeat by skin-sensitizing checmicals in transgenic mice

Authors

John D. Morrey, Utah State UniversityFollow
M K. Jackson
Tom D. Bunch, Utah State UniversityFollow
R W. Sidwell, Utah State University

Document Type

Article

Journal/Book Title/Conference

Intervirology

Volume

36

Publication Date

1993

First Page

65

Last Page

71

Abstract

Topical dinitrochlorobenzene (DNCB) is often used for evaluating contact skin hypersensitivity in immunocompromised patients. We have determined, in this study, that topical application of DNCB alone, even without induction of contact skin hypersensitivity, was sufficient to observe activation of the human immunodeficiency virus promoter (long terminal repeat) in the skin of an HIV-1 long terminal repeat-luciferase transgenic mouse model. Such treatment might be contraindicative in patients infected with the human immunodeficiency virus, because in earlier studies DNCB-exposed skin dendritic cells might migrate into draining lymph nodes which play an important role in AIDS pathogenesis.

Recommended Citation

Morrey, J. D., M. K. Jackson, T. D. Bunch, and R. W. Sidwell. 1993. Activation of the human immunodeficiency virus type 1 long terminal repeat by skin-sensitizing chemicals in transgenic mice. Intervirology 36:65-71. PMID8294183