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Canine breeders who are breeding to improve genetics often utilize the ability to test breeding stock for deleterious alleles. A DNA sample, such as a cheek swab or blood sample, is sent to laboratory where they determine genotypes that the owner has requested to know. Once the breeder receives results, they are better able to plan crosses or decide if a dog should be castrated to avoid the inheritance of unwanted diseases. This is particularly important with purebred dogs due to the high ratio of homozygous alleles. I will be using canine DNA for the gene ABCB1 or Multidrug Resistance 1. Samples for this study were collected from the Miniature American Shepherd, Miniature Australian Shepherd, and Australian Shepherd breeds, all which are known to carry the ABCB1 gene. Paw Print Genetics (Spokane, WA) provided 6 DNA samples of known genotype for use as controls.

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