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Mesenchymal stem cell (MSC)-based therapies have great potential for treating many age-related diseases. When harvested from human bone marrow (hBM), these cells are relatively scarce and thus is is necessary for the cells to be expanded to achieve the necessary numbers needed for any therapeutic application and for many research applications. In order for the potential of MSCs to be unlocked, a strategy must be developed to expand these cells in the most efficient and effective way possible. Here we present a method to expand MSCs in a benchtop bioreactor with microcarriers and quantify the effect of the addition of bone marrow-high performance microenviroment (BM-HPME®) free protein (FP) on this expansion.

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