Zikavirus (ZIKV) is a mosquito-borne flavivirus(Fig. 1) that is closely related to Japanese encephalitis, West Nile, yellow fever, and dengue viruses. ZIKV was first discovered in Uganda in 1947, but it was not until recent outbreaks, such as through Micronesia in 2007 and through Brazil in 2015 (Fig. 2), that it has been found to be associated with neurological diseases such as Guillain-Barrésyndrome and microcephaly.
Dewey, Matthew J.; Frank, Jordan C.; Song, Byung-Hak; Yun, Sang-Im; and Lee, Young-Min, "Genetic Elements Involved in Zika Virus Neuropathogenesis" (2017). Biology Posters. Paper 197.