The Effect of PEO Ratio on Degradation, Calcification and Bone Bonding of PEO/PBT Copolymer (Polyactive)

Authors

C. A. van Blitterswijk, Leiden University
J. v.d. Brink, Leiden University
H. Leenders, Leiden University
D. Baaker, Leiden University

Abstract

In this study, we evaluated the effect of PEO/ PBT proportion on the behavior of a range of PEO/ PBT segmented copolymers (Polyactive) during subcutaneous and intrabony implantation in the rat. It was demonstrated that varying the PEO proportion affected degradation, calcification and bone-bonding. The PEO/PBT 70/30 and 60/40 showed extensive degradation after 1 year, PEO/PBT 55145 an intermediate degradation, and the 40/60 and 30170 copolymers showed little and hardly any degradation respectively. PEO content also affected the degree of calcification . PEO/PBT 70/30 showed extensive and early calcification whereas almost no calcification was seen with PEO/PBT 30170. Since calcified sites at the periphery of the polymeric implants were locations of preference for bone-bonding to occur, PEO/PBT proportion also influenced bone/PEO/PBT interactions. The materials with the highest PEO content most frequently showed morphological indications of bone-bonding , while the material with 30 % PEO showed no bone/biomaterial contact. The differences in bone-bonding activity were also reflected by the occurrence of an electron. dense zone at the bone-biomaterial interface which was morphologically similar to that observed for calcium phosphate ceramics.

Recommended Citation

van Blitterswijk, C. A.; Brink, J. v.d.; Leenders, H.; and Baaker, D. (1993) "The Effect of PEO Ratio on Degradation, Calcification and Bone Bonding of PEO/PBT Copolymer (Polyactive)," Cells and Materials: Vol. 3: No. 1, Article 2.
Available at: https://digitalcommons.usu.edu/cellsandmaterials/vol3/iss1/2