Synthesis of 12-HETE using asymmetric phase-transfer catalysis
A new method of asymmetric phase-transfer-catalyzed alkylation is described. The synthetic utility of this method is demonstrated with the total syntheses of kurasoin A, kurasoin B, and S-naproxenTM, with current work toward S-equol. This methodology is currently being applied to an improved asymmetric total synthesis of the natural compound 12-S-HETE.
Christiansen, M. A.; Andrus, M. B. “Synthesis of 12-HETE using asymmetric phase-transfer catalysis.” Abstracts of Papers, 236th ACS National Meeting, Salt Lake City, UT, United States, April 22-26, 2009. Oral presentation.