Title

Investigation of the Regioselectivity for the Staudinger Reaction and Its Application for the Synthesis of Aminoglycosides with N-1 Modification

Document Type

Article

Journal/Book Title

Journal of Organic Chemistry

Publication Date

5-1-2007

Publisher

American Chemical Society

Volume

72

Issue

11

First Page

4055

Last Page

4066

DOI

10.1021/jo062588j

Abstract

The criteria for controlling the regioselectivity of Staudinger reduction of azides have been investigated. These findings enable a convenient direct N-1 modification of the perazidoneamine and perazidoribostamycin resulting in the synthesis of aminoglycoside antibiotics with activity against drug-resistant bacteria.

Comments

PubMed PMID: 17465564; PubMed Central PMCID: PMC2553255

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