Investigation of the Regioselectivity for the Staudinger Reaction and Its Application for the Synthesis of Aminoglycosides with N-1 Modification
Journal of Organic Chemistry
American Chemical Society
The criteria for controlling the regioselectivity of Staudinger reduction of azides have been investigated. These findings enable a convenient direct N-1 modification of the perazidoneamine and perazidoribostamycin resulting in the synthesis of aminoglycoside antibiotics with activity against drug-resistant bacteria.
Li, J.; Chiang, F.-I.; Chen, H.-N.; Chang, C.-W. T. “Investigation of the Regioselectivity for Staudinger Reaction and Its Application for the Synthesis of Aminoglycosides with N-1 Modification.” J. Org. Chem. 2007, 72, 4055-4066. PubMed PMID: 17465564; PubMed Central PMCID: PMC2553255.