Synthesis and Antibacterial Activity Study of a Novel Class of Cationic Anthraquinone Analogs
Bioorganic & Medicinal Chemistry
An approach that combines solid phase and solution phase synthesis of oligosaccharides via the assistance of sonication has been developed. By employing the traceless linker, the designed oligosaccharides can be obtained in pure form and, more importantly, ready for incorporation to aglycons of interest via ‘Click’ chemistry or amide linkage. The overall strategy will facilitate the studies of roles of carbohydrates in bioactive compounds.
Zhang, J.; Redman, N.; Litke, P.; Zeng, J.; Zhan, J.; Chan, K. Y.; Chang, C.-W. T. “Synthesis and Antibacterial Activity Study of a Novel Class of Cationic Anthraquinone Analogs.” Bioorg. Med. Chem. 2011, 19, 498-503. PubMed PMID: 21111625