Title

Glycodiversification for the Synthesis of Kanamycin and Neomycin Class Aminoglycoside Antibiotics

Document Type

Book Chapter

Journal/Book Title

Frontiers in Modern Carbohydrate Chemistry

Publication Date

3-13-2007

First Page

307

Last Page

327

DOI

10.1021/bk-2007-0960.ch017

Abstract

Aminoglycosides are an important resource against infectious diseases. However, the prevalence of aminoglycoside resistant bacteria has limited their use and resulted in the need for novel aminoglycosides. Our group has synthesized two libraries of aminoglycosides: pyranmycin and kanamycin analogs, utilizing the glycodiversification concept. Several of them show promising activity against both susceptible and resistant strains of E. coli. The structure activity relationship of these compounds further provides information for the future designs of aminoglycoside.

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