Document Type
Article
Journal/Book Title
Tetrahedron Letters
Publication Date
11-4-2019
Publisher
Elsevier Ltd
Volume
61
Issue
1
First Page
1
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Last Page
7
Abstract
We here disclose the total syntheses of the natural polyphenol JBIR-94 and two nonnatural analogs, whose structures are of interest for their bioactivity potential as radical scavengers. Although we initially attempted this by dually acylating both of putrecine’s amine nitrogens in a single pot, our endeavors with this method (which has been successfully reported by other groups) proved ineffectual. We accordingly opted for the lengthier approach of acylating each amine individually, which gratuitously prevailed and also aligns with separate literature precedent. Moreover, we here share our analysis of these target compounds’ cytotoxicities and IC50 values against A549 (CCL-185) human small lung cancer cells.
Recommended Citation
Cathy L. Mangum, Mica B. Munford, Alyssa B. Sam, Sandra K. Young, Jeremy T. Beales, Yagya Prasad Subedi, Chad D. Mangum, Tanner J. Allen, Miranda S. Liddell, Andrew I. Merrell, Diana I. Saavedra, Becky L. Williams, Nicole Evans, Joseph L. Beales, and Michael A. Christiansen, The total syntheses of jbir-94 and two synthetic analogs and their cytotoxicities against a549 (ccl-185) human small lung cancer cells, Tetrahedron Letters 61 (2020), no. 1, 151360.
