Extracellular vs Intracellular Delivery of CO: Does It Matter for a Stable, Diffusible Gasotransmitter?

Document Type

Article

Journal/Book Title

Journal of Medicinal Chemistry

Publication Date

10-2-2019

Publisher

American Chemical Society

Award Number

NIH 1R15GM124596-01

Funder

NIH

Volume

62

Issue

21

First Page

9990

Last Page

9995

Abstract

Carbon monoxide (CO) is a gasotransmitter produced in humans. An essential unanswered question in the design of carbon monoxide releasing molecules (CORMs) is whether the delivery molecule should be localized extra- or intracellularly to produce desired biological effects. Herein we show that extracellular CO release is less toxic and is sufficient to produce an anti-inflammatory effect similar to that of intracellular CO release at nanomolar concentrations. This information is valuable for the design of CORMs.

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