Extracellular vs Intracellular Delivery of CO: Does It Matter for a Stable, Diffusible Gasotransmitter?
Journal of Medicinal Chemistry
American Chemical Society
Carbon monoxide (CO) is a gasotransmitter produced in humans. An essential unanswered question in the design of carbon monoxide releasing molecules (CORMs) is whether the delivery molecule should be localized extra- or intracellularly to produce desired biological effects. Herein we show that extracellular CO release is less toxic and is sufficient to produce an anti-inflammatory effect similar to that of intracellular CO release at nanomolar concentrations. This information is valuable for the design of CORMs.
Soboleva, Tatiana, et al. “Extracellular vs Intracellular Delivery of CO: Does It Matter for a Stable, Diffusible Gasotransmitter?” Journal of Medicinal Chemistry, vol. 62, no. 21, Nov. 2019, pp. 9990–95. DOI.org (Crossref), doi:10.1021/acs.jmedchem.9b01254.