Date of Award:

5-1-1977

Document Type:

Thesis

Degree Name:

Master of Science (MS)

Department:

Biology

Department name when degree awarded

Life Sciences:Biology

Committee Chair(s)

Paul B. Carter

Committee

Paul B. Carter

Committee

Ross A. Smart

Abstract

Through investigation of several antifungal agents, candicidin was chosen to replace nystatin in Thayer-Martin medium. This compound has proven to be nontoxic to Neisseria gonorrhoeae and more active against species of Candida than nystatin. Although unstable, its high activity against yeast and nontoxicity toward the gonococci allows it to be used in a concentration which gives a shelf life of at least seven weeks and still be economically feasible. In clinical comparisons Thayer-Martin with candicidin was as sensitive and more selective against yeast than Thayer-Martin with nystatin. Its use in Thayer-Martin medium has the potential of yielding greater recovery rates of N. gonorrhoeae.

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