Date of Award:

5-1-1980

Document Type:

Thesis

Degree Name:

Master of Science (MS)

Department:

Biology

Department name when degree awarded

Life Sciences:Biology

Committee Chair(s)

Rex S. Spendlove

Committee

Rex S. Spendlove

Abstract

MDBK,LLC-MK2 and Intestinal 407 were the most susceptible cell lines respectively in a comparison study using 12 continuous cell lines and reovirus serotypes 1, 2, and 3 isolated from sewage. In a similar study, MDBK cells, when compared to LLC-MK2 and BGM cells, were the most susceptible to sewage isolated, protamine precipitated reovirus, which had not been serotyped and had no previous cell contact. Sewage-isolated, protamine-precipitated reoviruses were also used in conjunction with MDBK cells in a comparative evaluation of immunofluorescent cell count (ICC) and a plaque assay procedures. The ICC assay detected higher reovirus titers in 18-24 hrs, considerably less time than the plaque assay. Reovirus in excess of 104 /liter of raw sewage was detected by the ICC assay method.

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