Date of Award:

5-1-1983

Document Type:

Dissertation

Degree Name:

Doctor of Philosophy (PhD)

Department:

Biology

Department name when degree awarded

Life Sciences:Biology

Committee Chair(s)

Gene W. Miller

Committee

Gene W. Miller

Abstract

The exposure of isolated plant mitochondria to solutions containing soluble fluorides results in abnormal physiologic activities. These aberrations include an increase of mitochondrial respiratory rates and decreases of the ADP/0 ratios. The changes of respiratory activity are an expression of a fluoride-induced chemiosmotic uncoupling of respiration and an inhibition of mitochondrial localized ATPase activity. The fluoride ion might be accumulating in the mitochondria via a nonionic diffusion gradient since no fluoride-induced mitochondrial membrane disruption could be detected.

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