Activating the production of antitumor chromomycins in Streptomyces roseiscleroticus
The biosynthetic gene cluster of the aureolic type antitumor drug chromomycin A3 from S. roseiscleroticus has been identified and characterized. In the gene cluster we identified two regulatory genes, SrcmRI is the activator while the SrcmRII is the repressor. Via the overexpression of SrcmRI and the deletion of SrcmRII, the production of chromomycin A2 and A3, which was silent in the wild-type, has been highly activated. Besides A2 and A3, some more chromomycin derivatives were observed, which may be potential medicine.
Sun, Lei, "Activating the production of antitumor chromomycins in Streptomyces roseiscleroticus" (2014). Graduate Research Symposium. Paper 92.