The microvascular system of the murine popliteal lymph node was investigated using scanning electron microscopy of microcorrosion casts. Time-dependent changes in the microvasculature following regional antigen challenge in normal and lymphocyte-depleted mice were studied. Normal lymph node microvasculature exhibited a significant increase in both the vascular bed and post-capillary venules containing high-endothelium in response to antigen challenge. Lymph nodes of lymphocyte-depleted mice showed no microvascular size increase following antigen challenge and a reduction in the amount of high-endothelium was observed.
Steeber, Douglas A.; Erickson, Chris M.; Hodde, Kees C.; and Albrecht, Ralph M.
"Vascular Changes in Popliteal Lymph Nodes due to Antigen Challenge in Normal and Lethally Irradiated Mice,"
Scanning Microscopy: Vol. 1
, Article 41.
Available at: https://digitalcommons.usu.edu/microscopy/vol1/iss2/41