Amphetamine-Induced Excitations Predominate in Single Neostriatal Neurons Showing Motor-Related Activity
Neostriatal single-unit activity was recorded in freely moving rats. A majority (62%) of the 24 recorded neurons were activated during motor behavior such as locomotion (n = 11) or head movements (n = 4). The behavioral response to amphetamine (1.0 mg/kg) was associated with increases (n = 17) or decreases (n = 7) in firing rate. A significantly greater proportion of motor-related neurons were excited by the drug compared to nonmotor-related cells. These results, which confirm the heterogeneity of amphetamine-induced effects in the neostriatum, indicate that the baseline motor-response characteristics of neostriatal neurons may determine their response to amphetamine.
Haracz JL, Tschanz JT, Greenberg J & Rebec GV. Amphetamine-induced excitations predominate in single neostriatal neurons showing motor-related activity. Brain Research 1989;489: 365-368.