Presenter Information

Liming Tan, Utah State University

Class

Article

College

College of Science

Department

Chemistry and Biochemistry Department

Faculty Mentor

Gang Li

Presentation Type

Oral Presentation

Abstract

In this study, we present a novel method for the efficient cycloaddition of aryl diazoacetates with both terminal alkynes and nitriles, employing a bioinspired cobalt complex as a catalyst. Our findings indicate that terminal alkynes react with aryl diazoacetates to yield a cyclopropenation product through a 2+1 cycloaddition reaction. Meanwhile, nitriles react with aryl diazoacetates to produce an oxazole product via a 2+3 cycloaddition reaction. These results have significant implications for the development of new synthetic routes towards cyclopropenation and oxazole compounds.

Location

Logan, UT

Start Date

4-11-2023 10:30 AM

End Date

4-11-2023 11:30 AM

Included in

Biochemistry Commons

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Apr 11th, 10:30 AM Apr 11th, 11:30 AM

Cycloaddition of Aryldiazoacetates With Terminal Alkynes and Nitriles via a Bioinspired Cobalt Complex

Logan, UT

In this study, we present a novel method for the efficient cycloaddition of aryl diazoacetates with both terminal alkynes and nitriles, employing a bioinspired cobalt complex as a catalyst. Our findings indicate that terminal alkynes react with aryl diazoacetates to yield a cyclopropenation product through a 2+1 cycloaddition reaction. Meanwhile, nitriles react with aryl diazoacetates to produce an oxazole product via a 2+3 cycloaddition reaction. These results have significant implications for the development of new synthetic routes towards cyclopropenation and oxazole compounds.