Class
Article
College
College of Science
Department
Chemistry and Biochemistry Department
Faculty Mentor
Gang Li
Presentation Type
Oral Presentation
Abstract
In this study, we present a novel method for the efficient cycloaddition of aryl diazoacetates with both terminal alkynes and nitriles, employing a bioinspired cobalt complex as a catalyst. Our findings indicate that terminal alkynes react with aryl diazoacetates to yield a cyclopropenation product through a 2+1 cycloaddition reaction. Meanwhile, nitriles react with aryl diazoacetates to produce an oxazole product via a 2+3 cycloaddition reaction. These results have significant implications for the development of new synthetic routes towards cyclopropenation and oxazole compounds.
Location
Logan, UT
Start Date
4-11-2023 10:30 AM
End Date
4-11-2023 11:30 AM
Included in
Cycloaddition of Aryldiazoacetates With Terminal Alkynes and Nitriles via a Bioinspired Cobalt Complex
Logan, UT
In this study, we present a novel method for the efficient cycloaddition of aryl diazoacetates with both terminal alkynes and nitriles, employing a bioinspired cobalt complex as a catalyst. Our findings indicate that terminal alkynes react with aryl diazoacetates to yield a cyclopropenation product through a 2+1 cycloaddition reaction. Meanwhile, nitriles react with aryl diazoacetates to produce an oxazole product via a 2+3 cycloaddition reaction. These results have significant implications for the development of new synthetic routes towards cyclopropenation and oxazole compounds.