Research on Capitol Hill

Presenter and Co-Presenter(s)

Jamie Kingsford, Utah State University

Faculty Mentor

Dr. Nicholas Dickenson


  • Shigella is a gram-negative, bacterial pathogen typically found in contaminated water sources.
  • Each year, Shigella is responsible for over 90 million infections and 100,000 deaths stemming from symptoms of severe dysentery, fever, nausea and vomiting.
  • A needle-like apparatus found on the surface of Shigella allows the bacterium to infect host cells.
  • Each needle-apparatus has an associated ATPase, a protein that can hydrolyze ATP into ADP and Pi.
  • The Shigella needle-apparatus ATPase Spa47 is predicted to provide the energy for infection.
  • Spa47 has been shown to be essential for infection – without Spa47, no infection will occur.
  • We were able to recombinantly express, purify, and characterize Spa47 for the first time.

Journal/Book Title/Conference

Research On Capitol Hill 2016

Document Type


Publication Date




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