Dr. Nicholas Dickenson
- Shigella is a gram-negative, bacterial pathogen typically found in contaminated water sources.
- Each year, Shigella is responsible for over 90 million infections and 100,000 deaths stemming from symptoms of severe dysentery, fever, nausea and vomiting.
- A needle-like apparatus found on the surface of Shigella allows the bacterium to infect host cells.
- Each needle-apparatus has an associated ATPase, a protein that can hydrolyze ATP into ADP and Pi.
- The Shigella needle-apparatus ATPase Spa47 is predicted to provide the energy for infection.
- Spa47 has been shown to be essential for infection – without Spa47, no infection will occur.
- We were able to recombinantly express, purify, and characterize Spa47 for the first time.
Research On Capitol Hill 2016
Kingsford, Jamie, "Potential regulation of deadly water-borne Shigella bacteria pathogenesis through the Shigella infection protein Spa47" (2016). Research on Capitol Hill. Paper 38.