Mona Buhusi and Catalin V. Buhusi
Chronic unpredictable stress (CUS) alters neurotransmission and remodels neural circuits involved in learning, attention and decision making.
Glial-derived neurotrophic factor (GDNF) is essential for the function of neurons. Regulation of GDNF during stress is linked to resiliency while the inability to regulate it causes behavioral alterations.
We investigated the effects of CUS on latent inhibition (LI), a measure of selective attention expressed in this model as freezing behavior.
Brown, Colten, "The Impact of Chronic Stress, Traumatic Experiences and Genes on Behavior" (2018). Research on Capitol Hill. Paper 83.