Model Adjustments for Individual Patients using Rocuronium
Description
Neuromuscular blocking agents are used in the operating room to allow safe intubation and prevent dangerous movement during surgery. Six patients scheduled for laparoscopic surgery were monitored throughout the operation. We then adjusted the pharmacodynamic model parameters to better fit individual patient responses. Adjusting the models as the patient began to recover provided significantly better prediction of recovery from rocuronium when adjusted at a train-of-four ratio of 0.3. When these predictions are displayed to an anesthesiologist, or an astronaut who may be less trained in anesthesia, they may help in determining if another bolus of rocuronium or a reversal agent should be administered, or when to expect spontaneous muscle activity for safe extubation.
Model Adjustments for Individual Patients using Rocuronium
Salt Lake Community College
Neuromuscular blocking agents are used in the operating room to allow safe intubation and prevent dangerous movement during surgery. Six patients scheduled for laparoscopic surgery were monitored throughout the operation. We then adjusted the pharmacodynamic model parameters to better fit individual patient responses. Adjusting the models as the patient began to recover provided significantly better prediction of recovery from rocuronium when adjusted at a train-of-four ratio of 0.3. When these predictions are displayed to an anesthesiologist, or an astronaut who may be less trained in anesthesia, they may help in determining if another bolus of rocuronium or a reversal agent should be administered, or when to expect spontaneous muscle activity for safe extubation.