Location

Orbital ATK Conference Center

Start Date

5-7-2018 11:05 AM

Description

Comparing genomes to identify polymorphisms is a difficult task, especially beyond single nucleotide polymorphisms. Polymorphism detection is important in disease association studies as well as in phylogenetic tree reconstruction. We present a method for identifying polymorphisms in genomes by using a modified version de Bruijn graphs, data structures widely used in genome assembly from Next- Generation Sequencing. Using our method, we are able to identify polymorphisms that exist within a genome as well as well as see graph structures that form in the de Bruijn graph for particular types of polymorphisms (translocations, etc.)

Comments

Session 3

Available for download on Tuesday, May 07, 2019

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May 7th, 11:05 AM

Genome Polymorphism Detection Through Relaxed de Bruijn Graph Construction

Orbital ATK Conference Center

Comparing genomes to identify polymorphisms is a difficult task, especially beyond single nucleotide polymorphisms. Polymorphism detection is important in disease association studies as well as in phylogenetic tree reconstruction. We present a method for identifying polymorphisms in genomes by using a modified version de Bruijn graphs, data structures widely used in genome assembly from Next- Generation Sequencing. Using our method, we are able to identify polymorphisms that exist within a genome as well as well as see graph structures that form in the de Bruijn graph for particular types of polymorphisms (translocations, etc.)