Due to kidney or liver failure, normally harmless doses of prescription drugs can have toxic effects leading to further medical complications (Ing, 1979). Those suffering from kidney and liver failure frequently suffer related and unrelated ailments, but are restricted on the medications and the amounts thereof. Site-‐ specific ailments such as arthritis, localized viral infections, neuropathic pain, and other illnesses could be treated with smaller doses if the treating drug were only made available at the targeted site. The project goal is to develop a drug delivery system using human serum albumin (HSA) as a carrier for anti-‐ inflammatory, antibiotic, antiviral, and antioxidant drugs. This drug delivery system is unique in using rapid-‐ sequence, local hyperthermia, hypothermia, and ultrasound at a specific site of interest in the body. The proposed system is designed for patients with compromised liver and kidney function who are unable to safely use normal, oral doses of these medication types.
Gertsch, Sara; Bedingfield, Sean; and Lawanto, Stephanie, "Targeted Drug Delivery System for Kidney and Liver Failure Patients Using Human Serum Albumin" (2014). Undergraduate Research and Creative Opportunities (URCO) Grant Program. Paper 1.