Reactogenicity is a characteristic of biocompatible materials that provokes the reparative and proliferative reaction of connective tissues, a compulsory stage of which is inflammation. Thus, reactogenicity studies should include experiments in vivo. A quantitative assessment of reactogenicity can be obtained by subcutaneous implantation of standard olive-shaped specimens covered by the biomaterial under study followed by biochemical, histological and scanning electron microscopical studies of the capsule developing around the implant. Reactogenicity of surgical threads is evaluated by semiquantitative histological analysis of the wound healing process after suture application. Biomaterial reactogenicity can be modified by changing the structure of the surface and its chemical characteristics, and in particular, by applying different biologically active substances including atrane-containing compounds. The reactogenicity indices suggested present the results of the interaction between the biomaterials and the cells.
Slutskii, Leonid I.; Sevastjanova, Natalya A.; Ozolanta, Ivetta L.; Kuzmina, Irina V.; and Dombrovska, Laimdota E.
"Reactogenicity of Biomaterials as Studied by Biochemical, Morphological and Ultrastructural Techniques,"
Cells and Materials: Vol. 2
, Article 4.
Available at: http://digitalcommons.usu.edu/cellsandmaterials/vol2/iss2/4