In-Vivo Reactions in Some Bioactive Glasses and Glass-Ceramics Granules

Authors

A. M. Gatti, Universita' di Modena, Italy
T. Yamamuro, University of Kyoto
L. L. Hench, University of Florida
O. H. Andersson, Abo Akademi University, Turku

Abstract

Two different bioactive glasses and one glass-ceramic were implanted as granules for 2 months in rabbit muscle and for 5 months in sheep jaw in order to study the influence of the biological surroundings on the reactions of the materials.

Scanning electron microscope and energy dispersive X-ray microanalysis showed that a calcium and phosphorous-rich (CaP) surface layer (adjacent to a silicon rich-layer) forms on both glasses in both implantation sites. The glass-ceramic developed only a CaP layer. A chemical process of degradation was more evident in muscle, even though the implantation time was shorter than that in bone. For all materials, a chemical bond with bone occurs. The amount of new formed bone was different for the three materials.

Aging of the most reactive glass is hypothesized to explain a rapid loss of silicon by diffusion, as indicated by infrared spectroscopy.

Recommended Citation

Gatti, A. M.; Yamamuro, T.; Hench, L. L.; and Andersson, O. H. (1993) "In-Vivo Reactions in Some Bioactive Glasses and Glass-Ceramics Granules," Cells and Materials: Vol. 3: No. 3, Article 5.
Available at: https://digitalcommons.usu.edu/cellsandmaterials/vol3/iss3/5