Scanning electron microscopy (SEM) of red blood cells in whole blood samples from rats was performed following acute γ-irradiation of animals with 0.25 to 1 Gy. Increased incidence of echinocytosis was observed and found to be dose- and time-dependent. At a higher radiation dose (1 Gy), echinocytosis was revealed within 5 minutes after treatment and persisted up to 3 weeks. The data demonstrate the applicability of SEM for detecting minimal radiation-induced lesions of red blood cells.
Zharskaya, V. D. and Chukhlovin, A. B.
"Early Post-Radiation Changes of Red Blood Cell Shape in Rats,"
Scanning Microscopy: Vol. 10
, Article 22.
Available at: https://digitalcommons.usu.edu/microscopy/vol10/iss1/22