Ab initio investigation of interactions between models of local anesthetics and receptor: Complexes involving amine, phosphate, amide, Na+, K+, Ca2+, and Cl–

Document Type

Article

Journal/Book Title

Journal of Pharmaceutical Sciences

Publication Date

4-1988

Publisher

Wiley-Blackwell

Volume

77

Issue

4

First Page

304

Last Page

308

Abstract

Ab initio molecular orbital methods are used to study the interactions between models of local anesthetic molecules and the putative receptors within the nerve membrane: phospholipids and lipoproteins. The tertiary amine terminus of local anesthetics was modeled by ionized and un-ionized trimethylamine, while phosphate monoanion and formamide emulated the appropriate portions of the receptor. The protonated amine forms a very strong complex with the phosphate anion in which the charge is transferred to the phosphate. While somewhat weaker than this, the complex involving the amine (in either its ionized or un-ionized state) and peptide is considerably stronger than interpeptide H bonds, suggesting the anesthetic can disrupt the normal H-bond patterns in a protein. On the other hand, such interactions must compete with the rather tight binding of the anesthetic with the Na+, K+, Ca2+ and Cl– ions present in vivo.

Comments

http://onlinelibrary.wiley.com/doi/10.1002/jps.2600770404/abstract

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Published by Wiley-Blackwell in Journal of Pharmaceutical Sciences.

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