Date of Award:

5-2015

Document Type:

Dissertation

Degree Name:

Doctor of Philosophy (PhD)

Department:

Biological Engineering

Committee Chair(s)

Yue Cui

Committee

Yue Cui

Committee

Ronald Sims

Committee

Anhong Zhou

Committee

Ling Liu

Committee

Jixun Zhan

Abstract

Bio-nanotechnology refers to the field of science that intersects nanotechnology with biology. The study involves in the creation of bio-mimetic devices that emulate elements and systems of nature finding use in various applications. Nanotechnology involves the characterization of nanomaterials along with the study of molecular self-assembly and nanoelectronics. Controlled binding and assembly of proteins onto nanomaterials is at the core of biological materials science and engineering with wide-ranging applications. This hybrid technology opens up several avenues in the field of sensors, pharmaceuticals, artificial implants and so on.

In this work, different biomaterials and polymers were characterized for phage displayed peptide recognition moieties, followed by designing bifunctional entities of these peptides to construct devices of biological or electrical importance. Further, the instability of these nanomaterials was exploited to create nano/micropatterns, which could also be transferred to other substrates or subjected to self-assembly, creating bottom-up or top down fabrication systems. Finally, cumulating the techniques of microfluidics and immunoassay, a biosensor was designed to enable the detection of cardiac markers.

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