Date of Award:

5-1981

Document Type:

Thesis

Degree Name:

Master of Science (MS)

Department:

Animal, Dairy, and Veterinary Sciences

Department name when degree awarded

Graduate Program in Toxicology

Committee Chair(s)

Joseph C. Street

Committee

Joseph C. Street

Committee

William A. Brindly

Committee

Arthur W. Mahoney

Abstract

Exposure to halogenated phenols and pyridinols is of increasing concern because of their wide use and distribution. This research was initiated to determine the distribution, accumulation, and depletion of a group of halogenated phenols and a pyridinol in selected tissues of male weanling rats at different time intervals following a single oral dose of 0.33 or 1.66 m moles per kg body weight. The halogenated phenols and pyridinol were distributed differently in every tissue sampled following their administration, even though the amount administered was the same in each case. The concentrations in tissue were found in the order: 2,4,5-trichlorophenol > 4-bromo-2,5-dichlorophenol > 4-iodo-2,5-dichlorophenol > 3,5,6-trichloro-2-pyridonol in kidney and fat, whereas the series 3,5,6-trichloro-2-pyridinol > 4-iodo-2,5-dichlorophenol > 4-bromo-2,5-dichlorophenol > 3,5,6-trichlorophenol occurred in liver. No structurally significant series was observed for their concentrations in blood.

All halogenated phenols and pyridinol concentrations in tissues declined rapidly with time but not always in an apparently log linear fashion. Rates were greatest for clearance from blood. The highest concentration of halogenated phenols was in kidney among the tissues studied, whereas the highest concentration of halogenated pyridinol was in liver.

Relationships were found between the relative lipophilicity, as indicated by the chromatographic Rm value, and the concentrations of these compounds in tissues. The RH (i.e., relative lipophilicity) was generally very well correlated with the log concentration of compounds in tissues observed 24 h after dosing. The correlation coefficients ranged between .517 and .995 among tissues. Correlations were positive between the Rm values and 24 h concentrations in adipose tissue, and kidney, but negative for the relationship between the Rm and 24 h concentrations in blood and liver.

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