Date of Award:
5-2015
Document Type:
Dissertation
Degree Name:
Doctor of Philosophy (PhD)
Department:
Chemistry and Biochemistry
Committee Chair(s)
Cheng-Wei Tom Chang
Committee
Cheng-Wei Tom Chang
Committee
Alvan C. Hengge
Committee
Bradley S. Davidson
Committee
Lisa M. Berreau
Committee
Jon Y. Takemoto
Abstract
For the first project, a library of fifteen commercially purchased and synthetic fluorogenic probes were employed for the investigation of biomass degradation using extract of white-rot fungi. These discoveries prove that it is possible to employ fungi for selective degradation or release of hemicelluloses from biomass. This work is supported by Sun Grant Western Regional Center/DOT "Bioprospecting for Enzymes to Break Lignin-Hemicellulose Bond" ($300,000,09/01/2011-08/31/2013)
The second project is focused on synthesizing new aminoglycoside analogs and exploring the potential to revive traditional antibacterial kanamycin as new type of antifungal agents. Although aminoglycosides antibiotics are mainly used as antibacterial agents, this project prove that it is possible to convert kanamycin to amphiphilic antifungal agents through simple chemical modification.
Checksum
5628e5a2b4c6708e2b96ef14f35fc846
Recommended Citation
Zhang, Qian, "Synthesis of Fluorogenic Probes for Studying Biomass Degradation and Synthesis of New Antifungal Aminoglycosides" (2015). All Graduate Theses and Dissertations, Spring 1920 to Summer 2023. 4472.
https://digitalcommons.usu.edu/etd/4472
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