Title

Toxins from the entomogenous fungus Metarrhizium anisopliae: Isolation of destruxins from submerged cultures

Document Type

Article

Journal/Book Title/Conference

Journal of Invertebrate Pathology

Volume

14

Issue

1

Publication Date

7-1-1969

First Page

82

Last Page

88

DOI

10.1016/0022-2011(69)90012-3

Abstract

Destruxins A and B, two depsipeptides toxic to insects, were present in submerged cultures of a North American isolate of Metarrhizium anisopliae. The fungus produced additional, unidentified compounds which also induced tetanic paralysis in larvae of the greater wax moth, Galleria mellonella. An isolation technique using carbon tetrachloride extraction of unfiltered liquid cultures as the initial step (in place of charcoal adsorption from culture filtrates) was developed to facilitate isolation of destruxins from large volumes of medium.

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