Proceedings of the National Academy of Sciences
National Academy of Sciences
USDA, National Institute of Food and Agriculture (NIFA) 2018-67014-27542
USDA, National Institute of Food and Agriculture (NIFA)
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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Developmental plasticity generates phenotypic variation, but how it contributes to evolutionary change is unclear. Phenotypes of individuals in caste-based (eusocial) societies are particularly sensitive to developmental processes, and the evolutionary origins of eusociality may be rooted in developmental plasticity of ancestral forms. We used an integrative genomics approach to evaluate the relationships among developmental plasticity, molecular evolution, and social behavior in a bee species (Megalopta genalis) that expresses flexible sociality, and thus provides a window into the factors that may have been important at the evolutionary origins of eusociality. We find that differences in social behavior are derived from genes that also regulate sex differentiation and metamorphosis. Positive selection on social traits is influenced by the function of these genes in development. We further identify evidence that social polyphenisms may become encoded in the genome via genetic changes in regulatory regions, specifically in transcription factor binding sites. Taken together, our results provide evidence that developmental plasticity provides the substrate for evolutionary novelty and shapes the selective landscape for molecular evolution in a major evolutionary innovation: Eusociality.
Karen M. Kapheim, Beryl M. Jones, Hailin Pan, Cai Li, Brock A. Harpur, Clement F. Kent, Amro Zayed, Panagiotis Ioannidis, Robert M. Waterhouse, Callum Kingwell, Eckart Stolle, Arián Avalos, Guojie Zhang, W. Owen McMillan, & William T. Wcislo. 2020. Developmental plasticity shapes social traits and selection in a facultatively eusocial bee. Proceedings of the National Academy of Sciences Jun 2020, 117 (24) 13615-13625; https://doi.org/10.1073/pnas.2000344117