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Utah State University


These studies were designed to elucidate the role of ovarian senescence in the increased susceptibility for postmenopausal females to become subject to disease when compared to premenopausal females. Current dogma hypothesizes that the inability of the senescent ovaries to produce hormones for the reproductively senescent female is responsible for the increase in disease. Preliminary lab work has shown that depletion of germ cells from the ovaries of a young mouse, then a transplanting the germ cell depleted ovaries to a postreproductive mouse produced improved health shown through increased life span and decreased cardiovascular and orthopedic diseases.

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