Enterovirus D68 (EV-D68) is an emerging picornavirus virus which typically causes respiratory disease. In 2014, a nationwide outbreak of EV-D68 occurred, with a portion of these cases associated with neurological disease. At the time of this outbreak, no animal models existed for Enterovirus D68, making it difficult to characterize pathology and test potential therapeutics. To address this, we developed a mouse model of EVd68 infection in AG-129 mice (immuno-compromised mice).
McClatchy, John; Evans, Joseph; Hurst, Brett; and Tarbet, Bart, "Development of Murine Model for Enterovirus D68 in AG-129 Mice" (2017). Biology Posters. Paper 189.