Ingredients Necessary for Proton Transfer in Enzymes
Israel Journal of Chemistry
The transfer of a proton across a hydrogen bond can be influenced by a number of factors, including H-bond length, intramolecular angles, and the presence of neighboring groups. The ability of different factors to push a proton across the H-bond is examined for a specific and very important pair of catalytic groups, Ser-195 and His-57, within the context of a serine proteinase enzyme. The influence of residue Asp-102 is considered for different charge states, as is the nature of the surrounding medium. Also examined are the perturbations introduced by the substrate and external ions and dipoles.
Ingredients Necessary for Proton Transfer in Enzymes S. Scheiner Isr. J. Chem. 2009 49 139-147
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Published by Wiley-Blackwell in Israel Journal of Chemistry