Title

Ingredients Necessary for Proton Transfer in Enzymes

Document Type

Article

Journal/Book Title

Israel Journal of Chemistry

Publication Date

7-2009

Publisher

Wiley-Blackwell

Volume

49

Issue

2

First Page

139

Last Page

147

DOI

10.1560/IJC.49.2.139

Abstract

The transfer of a proton across a hydrogen bond can be influenced by a number of factors, including H-bond length, intramolecular angles, and the presence of neighboring groups. The ability of different factors to push a proton across the H-bond is examined for a specific and very important pair of catalytic groups, Ser-195 and His-57, within the context of a serine proteinase enzyme. The influence of residue Asp-102 is considered for different charge states, as is the nature of the surrounding medium. Also examined are the perturbations introduced by the substrate and external ions and dipoles.

Comments

http://onlinelibrary.wiley.com/doi/10.1560/IJC.49.2.139/full

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Published by Wiley-Blackwell in Israel Journal of Chemistry

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