Title

One-pot Synthesis of 1- and 2-Substituted Naphtho[2,3-d][1,2,3]triazole-4,9-diones

Document Type

Article

Journal/Book Title

Journal of Organic Chemistry

Publication Date

5-5-2009

Publisher

American Chemical Society

Volume

74

Issue

11

First Page

4414

Last Page

4417

DOI

10.1021/jo9004926

Abstract

A one-pot three-component [2+3] cycloaddition for the synthesis of 1-alkyl 1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione and 2-alkyl 2H-naphtho[2,3-d][1,2,3]triazole-4,9-dione has been developed. By taking the advantage of difference in basicity, both products can be obtained in good purity. The unique heterocyclic scaffolds of these two products could exert interesting chemical and biological properties. The synthetic protocol is concise and suitable for scale-up synthesis of the desired products.

Comments

PubMed PMID: 19415905

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